Research is focused on understanding the cellular, molecular and genomic substrate(s) of CNS disorders and the underlying mechanisms. A multifaceted approach is used that might utilize studies in whole animals, isolated rains structures,neuronsal cell cultures or artificial systems. Techniques include: animal modeling and treatment; behavioral testing; neuroreceptor, transporter, and enzyme assays, HPLC, RIA, immunoblots; ELISA; PCR, immunohistochemistry; in situ hybridization; imaging; and others.
1. Neurotrophic factor signaling and neuroplasticity.
2. Opioid systems and nicotine addiction.
3. Regulation of membrane transporters.
4. Molecular mechanisms of GM1 ganglioside’s neurorestorative action in models of Parkinson’s Disease.